Triethylamine → HCID 69591893, compound

Participants

Reaction Steps

A solution of 4-(2-aminoethyl)pyridine (0.017 g, 0.14 mmol) in 0.3 mL methylene chloride was added to 3-{4-[[3-(tetrahydro-pyran-2-yloxy)-benzyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-phenyl}-acrylic acid (0.050 g, 0.09 mmol). Triethylamine (0.07 mL, 0.50 mmol), 1-propanephosphonic acid cyclic anhydride (0.06 mL of a 50 wt. % solution in ethyl acetate, 0.20 mmol), and catalytic DMAP were added. The reaction mixture was stirred at room temperature for 24 hr. Saturated aqueous sodium bicarbonate was added and the aqueous solution was washed with methylene chloride. The organic layer was separated, PS-trisamine resin (0.050 g) was added, and the mixture was stirred at room temperature for three days. The resin was filtered off and the filtrate was concentrated to afford 0.059 g of the title compound of Step A. MS 640.4 (M+1)+

Provenance & Evidence