Water → HCID 69591925, compound

Participants

Reaction Steps

To a solution of 1-morpholin-4-yl-3-{4-[4-(tetrahydro-pyran-2-yloxy)benzylamino]-phenyl}-prop-2-en-1-one (0.115 g, 0.27 mmol) and triethylamine (0.100 mL, 0.72 mmol) in 3 mL methylene chloride was added 4-methoxybenzenesulfonyl chloride (0.065 g, 0.31 mmol). The reaction mixture was stirred at room temperature for 60 h. Water was added and the aqueous solution was washed with methylene chloride (3×). The combined organic layers were dried (magnesium sulfate) and concentrated. Medium pressure silica gel chromatography (50% ethyl acetate/hexanes) gave the title compound of Step B.

Provenance & Evidence