HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1827685Generated: October 30, 2026
Potassium Carbonate → 3-(2-Methyl-pyrimidin-5-yl)-7-oxo-9-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-non-5-enoic acid ethyl ester
https://huagongshe.com/reaction/1827685
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [2-Oxo4-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-butyl]-phosphonic acid dimethyl ester | HCID 22082659 | — |
| Reactant | 3-(2-Methyl-pyrimidin-5-yl)-5-oxo-pentanoic acid ethyl ester | HCID 23581280 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(2-Methyl-pyrimidin-5-yl)-7-oxo-9-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-non-5-enoic acid ethyl ester | HCID 69372139 | — |
Reaction Steps
To a mixture of 4-10 (100 mg, 0.42 mmol) and 4-6 (160 mg, 0.54 mmol) in DMF (3 mL) was added K2CO3 (87 mg, 0.63 mmol) followed by heating to 50° C. for 18 hours. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 70:25:5 CHCl3/EtOAc/MeOH) to give 4-11 as a clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07056909B2 |
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| Source dataset | uspto-grants-2006_06 |
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| ORD ID | ord-19a250a590354e3a898edbcb4e9141c1 |
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| Source note | uspto-grants-2006_06 |
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