Acridan → n-[(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methyl]-9,10-dihydroacridine

Participants

Role	Name	HCID	Charge
Reactant	Acridan	HCID 7106	—
Reactant	Sodium hydride	HCID 24758	—
Reactant	6-[(N-phenylanilino)methyl]pteridine-2,4-diamine	HCID 486242	—
Reactant	2,4-Diamino-6-bromomethylpyrido[3,2-d]pyrimidine hydrobromide	HCID 22062982	—
Product	n-[(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methyl]-9,10-dihydroacridine	HCID 9950481	—

Reaction Steps

N-[(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methyl]-9,10-dihydroacridine (Formula I: Ar=2,4-diaminopyrido[3,2-d]pyrimidin-6-yl; W=CH2; X=N; Z=CH2; m=n=0) is prepared similarly to N-[(2,4-diaminopteridin-6-yl)methyl]-N,N-diphenylamine as disclosed above by using 9,10-dihydroacridine (134 mg, 0.8 mmol), NaH (50 mg, 2.1 mmol), and 2,4-diamino-6-bromomethylpyrido[3,2-d]pyrimidine hydrobromide (100 mg, 0.3 mmol). The product can be purified by chromatography.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07056911B1
Source dataset	uspto-grants-2006_06
ORD ID	ord-8c5a455e48c04cf5a50fcbb2694b70a4
Source note	uspto-grants-2006_06