Phenothiazine → 9-[(2,4-Diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]phenothiazine

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Reaction Steps

9-[(2,4-Diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]phenothiazine (Formula I: Ar=2,4-diaminopyrido[2,3-d]pyrimidin-6-yl; W=CH2; X=N; Z=S; m=n=0) is prepared similarly to N-[(2,4-diaminopteridin-6-yl)methyl]-N,N-diphenylamine as disclosed above by starting from phenothiazine (159 mg, 0.8 mmol), NaH (50 mg, 2.1 mmol), and 2,4-diamino-6-bromomethylpyrido[2,3-d]pyrimidine hydrobromide (100 mg, 0.3 mmol). The product can be purified by chromatography.

Provenance & Evidence