HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 9-[(2,4-Diaminopyrimidin-5-yl)methyl]-9,10-dihydrodibenz[b,f]azepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-[(N-phenylanilino)methyl]pteridine-2,4-diamine | HCID 486242 | — |
| Reactant | 5-(Bromomethyl)pyrimidine-2,4-diamine hydrobromide | HCID 22062981 | — |
| Reactant | 9,10-Dihydrodibenz[b,f]azepine | HCID 69591429 | — |
| Product | 9-[(2,4-Diaminopyrimidin-5-yl)methyl]-9,10-dihydrodibenz[b,f]azepine | HCID 69591133 | — |
Reaction Steps
9-[(2,4-Diaminopyrimidin-5-yl)methyl]-9,10-dihydrodibenz[b,f]azepine (Formula I: Ar=2,4-diaminopyrimidin-5-yl; W=CH2; X=N; Z=CH═CH; m=n=0) is prepared similarly to N-[(2,4-diaminopteridin-6-yl)methyl]-N,N-diphenylamine as disclosed above by using 9,10-dihydrodibenz[b,f]azepine (158 mg, 0.8 mmol), NaH (50 mg, 2.1 mmol), and 2,4-diamino-5-bromomethylpyrimidine hydrobromide (86 mg, 0.3 mmol). The product can be purified by chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07056911B1 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-9e038303e79e4d039732e6b77794cbef |
| Source note | uspto-grants-2006_06 |