Acetic Acid → HCID 22063001, compound

Participants

Reaction Steps

A solution of benzhydrylamine (366 mg, 2.0 mmol) and 2,4,6-triaminopyrido[2,3-d]pyrimidine (350 mg, 2.0 mmol) in a mixture of DMF (40 mL) and glacial AcOH (4 mL) is treated with BH3.Et3N (75 mg, 6.6 mmol), and the mixture is stirred at room temperature overnight, then diluted with H2O (20 mL) to decompose any unreacted reducing agent. The solvents are evaporated under reduced pressure, and the residue is purified on a silica gel column using 5-15% CHCl3 in MeOH as the eluent. Pooling and evaporation of appropriate fractions yields the title compound, N-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)benzhydrylamine.

Provenance & Evidence