Acetone → 1-(3,5-Difluorophenyl)-2-methylpropan-2-ol

HRID 1827761Notes

Reaction equation

HRID 1827761 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:10])[CH:9]=1)[CH2:5]Br.[CH3:11][C:12]([CH3:14])=[O:13]>>[F:1][C:2]1[CH:3]=[C:4]([CH2:5][C:12]([CH3:14])([OH:13])[CH3:11])[CH:7]=[C:8]([F:10])[CH:9]=1

Participants

3

Reactant 2

HCID 180AcetoneHCID 5188963,5-Difluorobenzyl bromide

Product 1

HCID 220634951-(3,5-Difluorophenyl)-2-methylpropan-2-ol

Procedure

The target compound is obtained by reacting a Grignard compound, prepared from 25.0 g (121 mmol) of 3,5-difluorobenzyl bromide, with 12.6 mL (171 mmol) of acetone. Yellow oil. Yield: 13.5 g (60%).

Workup

  1. customThe target compound is obtained

Sources & evidence

ORD record
ord-257f4f78cac4448690264715c6c5c0c6
Source dataset
uspto-grants-2006_06
Patent number
US07056916B2

Reaction notes

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