反应详情

1.5 g (2.8 mmol) of 6-benzyloxy-8-{2-[2-(4-ethoxyphenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}4H-benzo[1,4]oxazin-3-one in 80 mL methanol are hydrogenated with 250 mg palladium on charcoal (10%) as catalyst at ambient temperature and normal pressure. The catalyst is suction filtered and the filtrate is evaporated down. The residue is dissolved in 5 mL ethanol by heating, seeded, and diluted with ethyl acetate. The solid precipitated is filtered off and washed. White solid. Yield 1.0 g (83%, hydrochloride); melting point: 232° C.–235° C.; mass spectrometry: [M+H]+=401.

1. filtrationfiltered
2. customthe filtrate is evaporated down
3. dissolutionThe residue is dissolved in 5 mL ethanol
4. temperatureby heating
5. additiondiluted with ethyl acetate
6. customThe solid precipitated
7. filtrationis filtered off
8. washwashed