HCID 22064538, compound → HCID 22064540, compound

HRID 1827901Notes

Reaction equation

HRID 1827901 reaction equation
[N:1]([CH:4]1[C:9]2=[C:10]3[C:19](=[C:20]([O:22][CH3:23])[CH:21]=[C:8]2[O:7][C:6]([CH3:31])([CH3:30])[CH:5]1[OH:32])[C:18](=[O:24])[C:17]1[CH:16]=[C:15]2[CH:25]=[CH:26][CH:27]=[CH:28][C:14]2=[CH:13][C:12]=1[N:11]3[CH3:29])=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][CH:4]1[C:9]2=[C:10]3[C:19](=[C:20]([O:22][CH3:23])[CH:21]=[C:8]2[O:7][C:6]([CH3:30])([CH3:31])[CH:5]1[OH:32])[C:18](=[O:24])[C:17]1[CH:16]=[C:15]2[CH:25]=[CH:26][CH:27]=[CH:28][C:14]2=[CH:13][C:12]=1[N:11]3[CH3:29]

Participants

4

Reactant 1

HCID 22064538HCID 22064538, compound

Product 1

HCID 22064540HCID 22064540, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution containing 0.2 g of the compound obtained in Step A and 0.09 g of Pd/C in 5 ml of ethanol is stirred at ambient temperature under an H2 atmosphere for 48 hours. The catalyst is then filtered off and the filtrate is concentrated in vacuo. The residue is chromatographed over silica (dichloromethane/methanol: 95/5), allowing the desired product to be isolated.

Workup

  1. filtrationThe catalyst is then filtered off
  2. concentrationthe filtrate is concentrated in vacuo
  3. customThe residue is chromatographed over silica (dichloromethane/methanol: 95/5)
  4. customto be isolated

Sources & evidence

ORD record
ord-4a488cf207a04bd48d415844c022c51c
Source dataset
uspto-grants-2006_06
Patent number
US07056929B2

Reaction notes

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