反应详情

To 178 mg of the compound obtained in Step 6 above in 10 ml of acetic acid and 1 ml of water there are added 621 mg of zinc wool. The reaction mixture is stirred at ambient temperature for 2.5 hours and is then filtered. The filtrate is made alkaline using 10% aqueous ammonium hydroxide solution; the precipitate formed is then separated off by filtration. The crude residue is purified by chromatography over silica gel (dichloromethane/methanol: gradient from 0.1 to 0.5%), allowing the expected product to be isolated.

1. filtrationis then filtered
2. customthe precipitate formed
3. customis then separated off by filtration
4. customThe crude residue is purified by chromatography over silica gel (dichloromethane/methanol: gradient from 0.1 to 0.5%)
5. customto be isolated