HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 3-[2(r)-{Hydroxycarbonylpropyl-amino}-2-phenylethyl]-5-(2-chlorophenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-pyrimidine-2,4(1h,3h)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Oxobutanoic acid | HCID 1112 | — |
| Reactant | 5-(2-chlorophenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[2(R)-amino-2-phenylethyl]-pyrimidine-2,4(1H,3H)-dione | HCID 21027675 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[2(r)-{Hydroxycarbonylpropyl-amino}-2-phenylethyl]-5-(2-chlorophenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-pyrimidine-2,4(1h,3h)-dione | HCID 21027673 | — |
Reaction Steps
To compound 2b (0.03 mmol) in 1 mL MeOH, succinic semialdehyde (0.03 mmol) was added followed by addition of 8 M BH3:Pyridine (0.03 mmol). After overnight shaking, the compound 2-1 was purified by prep. LC-MS. MS (CI) m/z 618.2 (MH+) tR=1.005 (method 1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07056927B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-7b30581cb2604e12a19abe8b55dbd3b2 |
| Source note | uspto-grants-2006_06 |