Potassium Carbonate → HCID 21027707, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl-pyrazole-3-carboxylate (980 mg, 7.0 mmol), 2-(2-bromoethoxy)-tetrahydro-2H-pyran (1.57 g, 7.5 mmol), potassium carbonate (1.01 g, 7.3 mmol) and lithium iodide (46.8 mg, 0.35 mmol) were dissolved in 1-methyl-2-pyrrolidinone (10 mL) and the reaction mixture heated to 80° C. for 24 hours. The reaction mixture was allowed to cool for 17 hours and then diluted with a mixture of ethyl acetate:water 1:1 (500 mL). The organic layer was washed with water (3×250 mL), dried over magnesium sulphate and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with cyclohexane:ethyl acetate 90:10 to 80:20 to 75:25 to 50:50. The appropriate fractions were combined and concentrated in vacuo to yield the title product.

Provenance & Evidence