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HRID 1827970作成日：2026年10月25日
Triethylamine → (R)-2-(5-Phenyl-benzofuran-2-ylmethoxycarbonylamino)-3-phenylpropionic Acid Methyl Ester
https://huagongshe.com/reaction/1827970
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methyl (R)-(+)-2-isocyanato-3-phenylpropionate | HCID 6558897 | — |
| 反応物 | 2-Hydroxymethyl-5-phenyl-benzofuran | HCID 11379094 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (R)-2-(5-Phenyl-benzofuran-2-ylmethoxycarbonylamino)-3-phenylpropionic Acid Methyl Ester | HCID 12990909 | 63.7% |
反応手順
A mixture of 2-hydroxmethyl-5-phenyl-benzofuran 17 (1.20 g, 5.85 mmole), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.2 g, 5.9 mmole), triethylamine (1.7 ml), and THF (30 ml) was heated to 50° C. under a nitrogen atmosphere for 6 hrs. The solvent was removed under reduced pressure and the residue was purified by chromatography giving about 1.6 g of (R)-2-(phenyl-benzofuran-2-ylmethoxycarbonylamino)-3-phenyl-propionic acid methyl ester 18, mp. 85–86° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07056903B2 |
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| 出典データセット | uspto-grants-2006_06 |
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| ORD ID | ord-b8142267aa1845b0bdc2de33c8b1f91e |
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| 出典メモ | uspto-grants-2006_06 |
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