4-(Aminomethyl)benzonitrile → HCID 22064698, compound

HRID 1828075Notes

Reaction equation

HRID 1828075 reaction equation
[CH2:1]([O:3][CH:4]([N:8]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[N:9]1)[C:5]([OH:7])=O)[CH3:2].[NH2:21][CH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[C:22]([C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH:28][C:5](=[O:7])[CH:4]([O:3][CH2:1][CH3:2])[N:8]2[CH:12]=[CH:11][C:10]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)=[N:9]2)=[CH:25][CH:24]=1)#[N:21]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 22064657HCID 22064657, compound

Product 1

HCID 22064698HCID 22064698, compound

Procedure

(RS)-Ethoxy-[3-(4-methoxy-phenyl)-pyrazol-1-yl]-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-ethoxy-2-[3-(4-methoxy-phenyl)-pyrazol-1-yl]-acetamide. White amorphous solid. MS 391.2 ([M+H]+)

Sources & evidence

ORD record
ord-334ca5a2e0df4cdc8d92a7187f1f561b
Source dataset
uspto-grants-2006_06
Patent number
US07056932B2

Reaction notes

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