HCID 11295862, compound → HCID 135499915, compound

Participants

Reaction Steps

To a stirred suspension of 10% Pd/C (10 mg) at r.t. in ethanol (2 ml) was added (RS)-2-[3-(2-benzyloxy-5-chloro-phenyl)-pyrazol-1-yl]-N-(4-carbamimidoyl-benzyl)-2-ethoxy-acetamide hydrochloride (100 mg). Stirring at r.t. under a hydrogen atmosphere was continued for 3 hrs. The catalyst was filtered off over a celite pad and washed with ethanol. The filtrate was concentrated to give (RS)-N-(4-carbamimidoyl-benzyl)-2-[3-(5-chloro-2-hydroxy-phenyl)-pyrazol-1-yl]-2-ethoxy-acetamide hydrochloride (48 mg) as off-white solid. MS 428.2 ([M+H]+)

Provenance & Evidence