HCID 22064710, compound → HCID 22064707, compound

Participants

Reaction Steps

To a stirred suspension of 10% Pd/C (214 mg) at r.t. in ethanol (4 ml) under an argon atmosphere was added of (RS)-N-(4-cyano-benzyl)-2-ethoxy-2-[3-(3-nitro-phenyl)-pyrazol-1-yl]-acetamide (2.1 g). The mixture was stirred at r.t. under a hydrogen atmosphere for 18 h. The catalyst was filtered over a celite pad and the cake was washed with ethanol. The filtrate was concentrated. The crude product was purified by chromatography (silica gel, gradient cyclohexane=>EtOAc) to give (RS)-2-[3-(3-amino-phenyl)-pyrazol-1-yl]-N-(4-cyano-benzyl)-2-ethoxy-acetamide (1.0 g) as off-white solid. MS 376.5 ([M+H]+)

Provenance & Evidence