Acetyl chloride → HCID 22064704, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred, cooled (0° C.) solution of (RS)-2-[3-(3-amino-phenyl)-pyrazol-1-yl]-N-(4-cyano-benzyl)-2-ethoxy-acetamide (117 mg, example 5.2) in dichloromethane (5 ml) under an argon atmosphere were added triethylamine (0.06 ml) and acetyl chloride (0.02 ml). Stirring at 0° C. was continued for 3 hrs. The mixture was diluted with EtOAc, washed with 1.0 N HCl and brine, dried (MgSO4), filtered and concentrated. The crude product was isolated by chromatography (silica gel, gradient CH2Cl2 to CH2Cl2/MeOH 9:1) to give 2-[3-(3-acetylamino-phenyl)-pyrazol-1-yl]-N-(4-cyano-benzyl)-2-ethoxy-acetamide (115 mg) as off-white solid. MS 418.2 ([M+H]+)

Provenance & Evidence