HCID 22064702, compound → HCID 135724450, compound

Participants

Reaction Steps

To a stirred suspension of (RS)-2-[3-(2-benzyloxy-phenyl)-4-methyl-pyrazol-1-yl]-N-(4-cyano-benzyl)-2-ethoxy-acetamide (1.2 g, example 10.2) at r.t. in ethanol (20 ml) under an argon atmosphere was added 10% Pd/C (60 mg). The mixture was then stirred under a hydrogen atmosphere for 18 h. The catalyst was filtered off and washed with ethanol. The filtrate was concentrated. The crude product was isolated by chromatography (silica gel, gradient cyclohexane=>cyclohexane/EtOAc 2:3) to give (RS)-N-(4-cyano-benzyl)-2-ethoxy-2-[3-(2-hydroxy-phenyl)-4-methyl-pyrazol-1-yl]-acetamide (428 mg) as white solid. MS 389.5 ([M−H]−)

Provenance & Evidence