Ethyl iodoacetate → HCID 69642985, compound

HRID 1828084Notes

Reaction equation

[C:1]([C:3]1[CH:29]=[CH:28][C:6]([CH2:7][NH:8][C:9](=[O:27])[CH:10]([O:24][CH2:25][CH3:26])[N:11]2[CH:15]=[C:14]([CH3:16])[C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[OH:23])=[N:12]2)=[CH:5][CH:4]=1)#[N:2].I[CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[CH2:35]([O:34][C:32](=[O:33])[CH2:31][O:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:13]1[C:14]([CH3:16])=[CH:15][N:11]([CH:10]([C:9](=[O:27])[NH:8][CH2:7][C:6]2[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:29][CH:28]=2)[O:24][CH2:25][CH3:26])[N:12]=1)[CH3:36]

Participants

Reactant 2

HCID 12183Ethyl iodoacetate

HCID 135724450HCID 135724450, compound

Product 1

HCID 69642985HCID 69642985, compound

Procedure

Using an analogous procedure as described in example 11.2 (RS)-N-(4-cyano-benzyl)-2-ethoxy-2-[3-(2-hydroxy-phenyl)-4-methyl-pyrazol-1-yl]-acetamide was reacted with ethyl iodoacetate to give (RS)-(2-{1-[(4-cyano-benzylcarbamoyl)-ethoxy-methyl]-4-methyl-1H-pyrazol-3-yl}-phenoxy)-acetic acid ethyl ester. White amorphous solid. MS 477.5 ([M+H]+)

Sources & evidence

ORD record: ord-28607cefb7e4471999e2768ec2ea05c7
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07056932B2

Reaction notes

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