Sodium → HCID 11214642, compound

Participants

Reaction Steps

To a stirred mixture of (RS)-(2-{1-[(4-carbamimidoyl-benzylcarbamoyl)-ethoxy-methyl]-4-methyl-1H-pyrazol-3-yl}-phenoxy)-acetic acid ethyl ester acetate (82 mg) at r.t. in ethanol/H2O 1:1 (2 ml) was added sodium hydroxyde (20 mg). Stirring was then continued for 2 h. The mixture was concentrated to leave an off-white paste. The crude product was isolated by chromatography (silica gel, EtOAc/acetone/H2O/HOAc 6:2:1:1) to give (RS)-(2-{1-[(4-carbamimidoyl-benzylcarbamoyl)-ethoxy-methyl]-4-methyl-1H-pyrazol-3-yl}-phenoxy)-acetic acid acetate (58 mg) as an off-white solid. MS 466.4 ([M+H]+)

Provenance & Evidence