HCID 11121820, compound → HCID 178468070, compound

HRID 1828103Notes

Reaction equation

[CH2:1]([O:3][CH:4]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH3:17])=[CH:13][CH:14]=2)[C:9]1=[O:18])[C:5]([OH:7])=O)[CH3:2].[CH2:19]([O:26][C:27](=[O:39])/[N:28]=[C:29](\[NH2:38])/[C:30]1[CH:35]=[CH:34][C:33]([CH2:36][NH2:37])=[CH:32][CH:31]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:19]([O:26][C:27](=[O:39])/[N:28]=[C:29](\[NH2:38])/[C:30]1[CH:31]=[CH:32][C:33]([CH2:36][NH:37][C:5](=[O:7])[CH:4]([O:3][CH2:1][CH3:2])[N:8]2[CH2:16][C:15]3[C:10](=[CH:11][C:12]([CH3:17])=[CH:13][CH:14]=3)[C:9]2=[O:18])=[CH:34][CH:35]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 11121820HCID 11121820, compound

HCID 22064701HCID 22064701, compound

Product 1

HCID 178468070HCID 178468070, compound

Procedure

According to general procedure C, (RS)-ethoxy-(6-methyl-1-oxo-1,3-dihydro-isoindol-2-yl)-acetic acid was reacted with [1-amino-1-(4-aminomethyl-phenyl)-meth-(Z)-ylidene]-carbamic acid benzyl ester to give (RS)-[1-amino-1-(4-{[2-ethoxy-2-(6-methyl-1-oxo-1,3-dihydro-isoindol-2-yl)-acetylamino]-methyl}-phenyl)-meth-(Z)-ylidene]-carbamic acid benzyl ester as light yellow foam, MS 515.5 ([M+H]+).

Sources & evidence

ORD record: ord-25ee22cb81314881b604f26ce689f5a4
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07056932B2

Reaction notes

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