HCID 22064679, compound → HCID 22064672, compound

Participants

Reaction Steps

To a solution of (RS)-N-(4-cyano-2-nitro-benzyl)-2-ethoxy-2-(4-methyl-1-oxo-1,3-dihydro-isoindol-2-yl)-acetamide (0.382 g) in ethyl acetate (9 ml) was added 10% Pd/C (190 mg) and the mixture vigorously stirred at r.t. under a hydrogen atmosphere for 16 h. The catalyst was filtered over a celite pad and the cake was carefully washed with ethyl acetate. The filtrate was evaporated to yield (RS)-N-(2-amino-4-cyano-benzyl)-2-ethoxy-2-(4-methyl-1-oxo-1,3-dihydro-isoindol-2-yl)-acetamide (0.354 g) as off-white foam, MS 379.4 ([M+H]+).

Provenance & Evidence