HCID 22064664, compound → HCID 22064712, compound

Participants

Reaction Steps

To a solution of (RS)-N-(4-cyano-2-nitro-benzyl)-2-ethoxy-2-(4-fluoro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide (0.310 g) in ethyl acetate (7.3 ml) was added 10% Pd/C (60 mg) and the mixture vigorously stirred at r.t. under a hydrogen atmosphere for 24 h. The catalyst was filtered off over a celite pad and the cake was carefully washed with ethyl acetate. The filtrate was evaporated to yield (RS)-N-(2-amino-4-cyano-benzyl)-2-ethoxy-2-(4-fluoro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide (0.293 g) as yellow viscous oil, MS 397.2 ([M+H]+).

Provenance & Evidence