HRID1828118

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69642060

未命名化合物

结构：Cl.Cl.N=C(NC(=O)OCc1ccccc1)c1ccc(CN)cc1

HCID141089245

Carbamic acid, [[4-(aminomethyl)phenyl]iminomethyl]-, phenylmethyl ester, dihydrochloride

C16H19Cl2N3O2

PRODUCTS

生成物

结构：COC(C(=O)NCc1ccc(/C(N)=N/C(=O)OCc2ccccc2)cc1)c1nc2ccccc2n1CCOCc1ccccc1

HCID178496436

未命名化合物

PROCEDURE

实验过程

According to general procedure C, (RS)-[1-(2-benzyloxy-ethyl)-1H-benzoimidazol-2-yl]-methoxy-acetic acid was reacted with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid benzyl ester dihydrochloride (CAS 172348-75-3) to give (RS)-[1-amino-1-[4-({2-[1-(2-benzyloxy-ethyl)-1H-benzoimidazol-2-yl]-2-methoxy-acetylamino}-methyl)-phenyl]-meth-(Z)-ylidene]-carbamic acid benzyl ester. Off-white gum.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-628f4163870644139909a18faef6bace
来源数据集: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07056932B2
来源说明: uspto-grants-2006_06

反应 SMILES

[CH2:1]([O:8][CH2:9][CH2:10][N:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=[C:12]1[CH:20]([O:24][CH3:25])[C:21](O)=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.Cl.[CH2:28]([O:35][C:36](=[O:48])[NH:37][C:38]([C:40]1[CH:45]=[CH:44][C:43]([CH2:46][NH2:47])=[CH:42][CH:41]=1)=[NH:39])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH2:28]([O:35][C:36](=[O:48])/[N:37]=[C:38](\[NH2:39])/[C:40]1[CH:41]=[CH:42][C:43]([CH2:46][NH:47][C:21](=[O:22])[CH:20]([C:12]2[N:11]([CH2:10][CH2:9][O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=2)[O:24][CH3:25])=[CH:44][CH:45]=1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1