反应详情

温度

22 °C

To a dry flask charged with a stir bar was added (3R)-(−)-1-benzyl-3-aminopyrrolidine (202 mg, 1.15 mmoles) (commercial from TCI-US), 1,3-Diethyl-2-oxo-2,3-dihydro-1H-benzoimidazole-5-carbaldehyde (250 mg, 1.15 mmoles), magnesium sulfate (500 mg) and 5 ml of dichloromethane (0.23 M). The flask was sealed with a plastic cap and the resulting mixture was stirred for 20 hours at 22° C. The mixture was filtered through a nylon disk via syringes, rinsing with dichloromethane and the yellow filtrate was concentrated to give 450 mg of the title compound as a yellow gum/foam.

1. additionTo a dry flask charged with a stir bar
2. customThe flask was sealed with
3. customa plastic cap
4. filtrationThe mixture was filtered through a nylon disk via syringes
5. washrinsing with dichloromethane
6. concentrationthe yellow filtrate was concentrated