反应详情

To a solution of 4-cyclobutylamino-3-nitro-benzoic acid methyl ester (18.959, 56.3 mmol) in ethyl alcohol (300 ml) in a Parr shaker was added 10% Pd/C (0.67 g). The reaction was subjected to an atmosphere of hydrogen (50 psi) until the consumption of hydrogen ceased (2 hours). The reaction mixture was filtered through a pad of Celite® and concentrated to give 15.94 g of 3-Amino-4-cyclobutylamino-benzoic acid methyl ester as a solid.

1. customThe reaction was subjected to an atmosphere of hydrogen (50 psi) until the consumption of hydrogen
2. custom(2 hours)
3. filtrationThe reaction mixture was filtered through a pad of Celite®
4. concentrationconcentrated