Sodium borohydride → HCID 22063868, compound

Participants

Reaction Steps

[4-(1,3-Diethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-3-m-tolyl-pyrazol-1-yl]-acetaldehyde is prepared according to the procedures described in Example 339. [4-(1,3-Diethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-3-m-tolyl-pyrazol-1-yl]-acetaldehyde (0.03 g) is diluted with methanol (0.5 mL) and is treated with sodium borohydride (0.005 g). The reaction is held at 23° C. for 20 hours. The product is purified on silica gel to give 1,3-Diethyl-5-[1-(2-hydroxy-ethyl)-3-m-tolyl-1H-pyrazol-4-yl]-1,3-dihydro-benzoimidazol-2-one.

Provenance & Evidence