1-(2-Fluorophenyl)piperazine → HCID 10451194, compound

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Reaction Steps

3-(Bromomethyl)-5-chloro-1-benzothiophene and 1-(2-fluorophenyl)piperazine were processed as described in Example 2 to provide the title compound. 1H NMR (d6-DMSO, 300 MHz) δ 2.65 (m, 2H), 3.02 (m, 6H), 3.78 (s, 2H), 6.92–7.10 (m, 4H), 7.40 (dd, 1H, J=8.7, 1.5), 7.67 (s, 1H), 7.78 (d, 1H, J=8.7 Hz), 8.06 (d, 1H, J=1.5 Hz). MS (DCI/NH3) m/z 361.0 (M+H)+. Anal. Calcd for C19H18N2SClF: C, 63.24; H, 5.03; N, 7.76. Found: C, 63.17; H, 4.90; N, 7.67.

Provenance & Evidence