Trifluoroacetic acid → HCID 22065959, compound

Participants

Reaction Steps

The product from Example 11B (0.48 g, 1.40 mmol) in CH2Cl2 (20 mL) was treated with TFA (20 mL) and stirred for 1 hour. The mixture was concentrated under reduced pressure and the residue was purified by flash chromatography (10% MeOH/CH2Cl2/1% NH4OH) to provide the title compound. 1H NMR (CD3OD, 300 MHz) δ 1.85–1.98 (m, 4H), 2.58–2.68 (m, 2H), 3.45–3.57 (m, 4H), 3.67 (s, 2H), 6.25 (s, 1H), 6.75–6.90 (m, 1H), 7.10–7.25 (m, 2H); MS (DCI/NH3) m/z 248 (M+H)+.

Provenance & Evidence