1-(2-Methoxyphenyl)piperazine → HCID 10065550, compound

HRID 1828277Notes

Reaction equation

HRID 1828277 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[CH:11]=O.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][N:24]([CH2:11][C:3]2[N:2]([CH3:1])[C:10]3[C:5]([CH:4]=2)=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 2671641-Methylindole-2-carboxaldehyde

Product 1

HCID 10065550HCID 10065550, compound

Procedure

1-Methyl-1H-indole-2-carbaldehyde and 1-(2-methoxyphenyl)piperazine were processed as described in Example 7 to provide the title compound. 1H NMR (CD3OD, 300 MHz) δ 3.0 (m, 2H), 3.45 (m, 2H), 3.74 (m, 4H), 3.86 (s, 3H), 3.88 (s, 2H), 4.70 (s, 3H), 6.83 (s, 1H), 6.90–7.14 (m, 5H), 7.28 (m, 1H), 7.48 (d, 1H, J=7.8 Hz), 7.62 (d, 1H, J=7.8 Hz). MS (DCI/NH3) m/z 336.1 (M+H)+. Anal. Calcd for C21H25N3O: C, 75.19; H, 7.51; N, 12.53. Found: C, 74.45; H, 7.43; N, 12.37.

Sources & evidence

ORD record
ord-55a632714c5b4bfb98bac9b0d1b2c202
Source dataset
uspto-grants-2006_06
Patent number
US07057042B2

Reaction notes

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