Formaldehyde → HCID 22065962, compound

HRID 1828282Notes

Reaction equation

HRID 1828282 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.[N:10]1([C:16]2[N:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[C:22]([O-])(=O)C.[Na+].C=O>>[N:21]1[CH:20]=[CH:19][CH:18]=[N:17][C:16]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:22][C:3]2[C:4]3[C:5](=[N:6][CH:7]=[CH:8][CH:9]=3)[NH:1][CH:2]=2)[CH2:12][CH2:11]1

Participants

5

Reactant 4

HCID 712FormaldehydeHCID 92221H-Pyrrolo(2,3-b)pyridineHCID 887471-(2-Pyrimidinyl)piperazineHCID 517045Sodium Acetate

Product 1

HCID 22065962HCID 22065962, compound

Procedure

1H-pyrrolo[2,3-b]pyridine (47 mg, 0.40 mmol), 2-(1-piperazinyl)pyrimidine (65 mg, 0.48 mmol), sodium acetate (72 mg, 0.53 mmol), and formaldehyde (0.48 mmol) were processed as described in Example 18 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ 2.42 (m, 4H) 3.68 (m, 4H) 4.05 (s, 2H) 5.59 (s, 1H) 6.60 (m, 1H) 7.08 (m, 2H) 7.37 (m, 2H 8.07 (m, 2H). (ESI) m/z 295 (M+H)+.

Sources & evidence

ORD record
ord-d3a99a2761084d1faa81a2c3b9056a59
Source dataset
uspto-grants-2006_06
Patent number
US07057042B2

Reaction notes

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