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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18283Generated: October 25, 2026

5-chloro-1-methyl-1H-indole-3-carbaldehyde → 5-chloro-1-methyl-3-(methylaminomethyl)-1H-indole

https://huagongshe.com/reaction/18283

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-chloro-1-methyl-1H-indole-3-carbaldehydeHCID 16723796—
ReactantMethyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139049—
Product5-chloro-1-methyl-3-(methylaminomethyl)-1H-indoleHCID 2213901793%

Reaction Steps

According to the procedure of Preparation 13 (c), except substituting 5-chloro-1-methyl-1H-indole-3-carboxaldehyde for the ,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (2.1 g, 93%) was obtained as an amber oil: MS (ES) m/e 209.0 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741339B2
Source datasetuspto-grants-2010_06
ORD IDord-1f60f64e365b4bac8c8133e5d94d27ce
Source noteuspto-grants-2010_06