Potassium Carbonate → HCID 178473790, compound

Participants

Reaction Steps

This reaction was carried out in a 50 ml round bottom flask. 4-{3-(1-Acetylpiperidin-4-yl)-5-(4-chlorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrazole-4-yl}pyrimidine (9) (0.5 g) charged to the reactor, followed by ethanol (5 ml), which, in turn, was followed by potassium carbonate (1 g). The mixture was stirred until completion of the reaction, as indicated by liquid chromatography. The ethanol was then removed in vacuo, and the resulting solid was dissolved in ethyl acetate. The organic layer washed with water, and concentrated in vacuo to yield a white solid. The product had the following characteristics: 1H NMR (CDCl3, 300 MHz) δ 9.27 (1H, s), 8.54 (1H, broad-s), 7.36 (4H, s), 7.01 (1H, d, J=5.1 Hz), 4.82–4.72 (1H, m), 4.02–3.90 (1H, m), 3.72–3.59 (1H, m), 3.30–3.18 (1H, m), 2.79–2.62 (1H, m), 2.18 (3H, s), 2.15–1.78 (4H, m).

Provenance & Evidence