Sodium Hydroxide → HCID 9840864, compound

Participants

Reaction Steps

This reaction was conducted in a 250 ml round bottom flask. To 4-{3-(1-acetylpiperidin-4-yl)-5-(4-chlorophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrazole-4-yl}pyrimidine (9) (6.86 g) was added 6 M HCl (40 ml). The mixture was stirred and heated to reflux. The reaction was monitored by HPLC, and determined to be complete after 2.5 hr. The mixture was then cooled in an ice/water bath, and 6 M NaOH was slowly added until the pH was between 13–14. The resulting product was isolated via vacuum filtration to yield 3.25 g of 4-[3-(4-chlorophenyl)-5-piperidine-4-yl-1H-pyrazol-4-yl]pyrimidine (79.8% yield) as a white solid.

Provenance & Evidence