化工社化工社 化学情報印刷レポート · 研究参考用
N-[tert-butoxycarbonyl]-L-serine → (R)-7-Amino-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[tert-butoxycarbonyl]-L-serine | HCID 98766 | — |
| 反応物 | (R)-2-tert-butoxycarbonylamino-3-hydroxy propionic acid | HCID 637603 | — |
| 反応物 | (S)-7-Amino-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one hydrochloride | HCID 18599716 | — |
| 生成物 | (R)-7-Amino-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one hydrochloride | HCID 69195062 | — |
反応手順
(R)-3-amino-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride salt was prepared from N-t-butyloxycarbonyl-D-serine by the procedures described in Itoh, et al., Chem. Pharm. Bull. 1986, 34, 1128–1147 for the preparation of (S)-3-amino-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride salt from N-t-butyloxycarbonyl-L-serine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07057046B2 |
| 出典データセット | uspto-grants-2006_06 |
| ORD ID | ord-dd1d913e30f7474a9569c091a1826ad6 |
| 出典メモ | uspto-grants-2006_06 |