HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 69195195, compound → (2S, 3S)-3-amino-2-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one trifluoroacetate salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 69195195 | HCID 69195195 | — |
| Reactant | HCID 69195949 | HCID 69195949 | — |
| Product | (2S, 3S)-3-amino-2-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one trifluoroacetate salt | HCID 69195761 | — |
Reaction Steps
(2S, 3S)-3-amino-2-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one trifluoroacetate salt was prepared from (2S,3S)-3-t-butyloxycarbonylamino-2-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one (Robl, et al., Bioorg. & Med. Chem. Lett. 1994, 4, 1789–1794) by treatment with a solution of trifluoroacetic acid—dichloromethane—tetrahydrofuran (1:10:10) at room temperature, followed by solvent evaporation and coevaporation with tetrahydrofuran under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07057046B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-70b92798d3d84cbe950c522743116fcc |
| Source note | uspto-grants-2006_06 |