Ammonia → HCID 22066028, compound

HRID 1828366Notes

Reaction equation

HRID 1828366 reaction equation
I[CH:2]1[C:12](=[O:13])[NH:11][C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][NH:5][C:4]=2[CH2:3]1.[NH3:14]>>[NH2:14][CH:2]1[C:12](=[O:13])[NH:11][C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][NH:5][C:4]=2[CH2:3]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22066021HCID 22066021, compound

Product 1

HCID 22066028HCID 22066028, compound

Procedure

Thus obtained 3-iodo-2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepin-2-one (109 mg) was dissolved in 7 M methanolic ammonia solution (5 mL) at room temperature under argon. When the starting material was consumed, the mixture was evaporated under vacuum, and the residue was purified by silica gel chromatography to obtain 3-amino-2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepin-2-one.

Workup

  1. customWhen the starting material was consumed
  2. customthe mixture was evaporated under vacuum
  3. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-dd7284dffb504dd9b452ed32bf9d12c0
Source dataset
uspto-grants-2006_06
Patent number
US07057046B2

Reaction notes

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