N-bromobutanimide → HCID 86589691, compound

Participants

Reaction Steps

2-(1,1-Dimethyl-2-(N-methoxyimino)ethylaminocarbonyl)-N-(6-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)-2-methylpyridin-3-yl)benzamide was treated in the same manner as in Example 36, except that the N-bromosuccinimide was replaced with N-iodosuccinimide, to obtain 2-(1,1-dimethyl-2-(N-methoxyimino)ethylaminocarbonyl)-N-(6-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)-2-methylpyridin-3-yl)-3-iodobenzamide (yield 83%, melting point 220° C.). Regioselectivity of iodination into the 3-position was 100%.

Provenance & Evidence