HCID 86588092, compound → HCID 22063667, compound

HRID 1828415Notes

Reaction equation

HRID 1828415 reaction equation
[CH:1]1([C:5]2[N:6]=[C:7]([CH2:10][CH2:11][C:12]3[CH:38]=[CH:37][N:15]4[C:16](=[O:36])[C:17](/[CH:27]=[CH:28]/[C:29]([O:31]C(C)(C)C)=[O:30])=[C:18]([N:20]5[CH2:25][CH2:24][CH2:23][CH:22]([OH:26])[CH2:21]5)[N:19]=[C:14]4[CH:13]=3)[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1>C(O)=O>[CH:1]1([C:5]2[N:6]=[C:7]([CH2:10][CH2:11][C:12]3[CH:38]=[CH:37][N:15]4[C:16](=[O:36])[C:17](/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30])=[C:18]([N:20]5[CH2:25][CH2:24][CH2:23][CH:22]([OH:26])[CH2:21]5)[N:19]=[C:14]4[CH:13]=3)[S:8][CH:9]=2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 1

HCID 86588092HCID 86588092, compound

Product 1

HCID 22063667HCID 22063667, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

tert-Butyl (E)-3-[8-[2-(4-Cyclobutyl-1,3-thiazol-2-yl)ethyl]-2-(3-hydroxy-piperidino)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-propenoate (76 mg, 0.142 mmol) was added with formic acid (3 ml) and stirred at room temperature for 2 hours and 30 minutes. After the formic acid was evaporated under reduced pressure, the residue was purified by thin layer silica gel chromatography (chloroform:methanol=15:1) to obtain 39 mg (55% for the three steps) of the title compound as yellow crystals.

Workup

  1. customAfter the formic acid was evaporated under reduced pressure
  2. customthe residue was purified by thin layer silica gel chromatography (chloroform:methanol=15:1)

Sources & evidence

ORD record
ord-13920e8a9bbc4e6fb333b60447ed5c9d
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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