HCID 22063667, compound → HCID 22063555, compound

HRID 1828418Notes

Reaction equation

HRID 1828418 reaction equation
[CH:1]1([C:5]2[N:6]=[C:7]([CH2:10][CH2:11][C:12]3[CH:34]=[CH:33][N:15]4[C:16](=[O:32])[C:17](/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30])=[C:18]([N:20]5[CH2:25][CH2:24]C[CH:22]([OH:26])[CH2:21]5)[N:19]=[C:14]4[CH:13]=3)[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C1(C2N=C(CCC3C=CN4C(=O)C(/C=C/C(OC(C)(C)C)=O)=C(N5CCOCC5)N=C4C=3)SC=2)CCC1>>[CH:1]1([C:5]2[N:6]=[C:7]([CH2:10][CH2:11][C:12]3[CH:34]=[CH:33][N:15]4[C:16](=[O:32])[C:17](/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30])=[C:18]([N:20]5[CH2:21][CH2:22][O:26][CH2:24][CH2:25]5)[N:19]=[C:14]4[CH:13]=3)[S:8][CH:9]=2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 22063667HCID 22063667, compoundHCID 86588093HCID 86588093, compound

Product 1

HCID 22063555HCID 22063555, compoundYield 73%

Procedure

Reactions were performed in the same manner as in Example 1, (L) by using tert-butyl (E)-3-{8-[2-(4-cyclobutyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate (127 mg, 0.2430 mmol) to obtain 82.7 mg (73%) of the title compound as yellow crystals.

Sources & evidence

ORD record
ord-8696f24300254ef2ad1190d4e7a023b0
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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