HCID 22063667, compound → HCID 22063583, compound

HRID 1828423Notes

Reaction equation

HRID 1828423 reaction equation
[CH:1]1([C:5]2[N:6]=[C:7]([CH2:10][CH2:11][C:12]3[CH:34]=[CH:33][N:15]4[C:16](=[O:32])[C:17](/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30])=[C:18]([N:20]5[CH2:25][CH2:24]C[CH:22]([OH:26])[CH2:21]5)[N:19]=[C:14]4[CH:13]=3)[S:8][CH:9]=2)[CH2:4]CC1.C(C1N=C(CCC2C=CN3C(=O)C(/C=C/C(OC(C)(C)C)=O)=C(N4CCOCC4)N=C3C=2)SC=1)C>>[CH2:1]([C:5]1[N:6]=[C:7]([CH2:10][CH2:11][C:12]2[CH:34]=[CH:33][N:15]3[C:16](=[O:32])[C:17](/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30])=[C:18]([N:20]4[CH2:21][CH2:22][O:26][CH2:24][CH2:25]4)[N:19]=[C:14]3[CH:13]=2)[S:8][CH:9]=1)[CH3:4]

Participants

3

Reactant 2

HCID 22063667HCID 22063667, compoundHCID 86588096HCID 86588096, compound

Product 1

HCID 22063583HCID 22063583, compoundYield 73%

Procedure

Reactions were performed in the same manner as in Example 1, (L) by using tert-butyl (E)-3-{8-[2-(4-ethyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-4-oxo-4H-pyrido-[1,2-a]pyrimidin-3-yl}-2-propenoate (144 mg, 0.290 mmol) to obtain 93 mg (73%) of the title compound as yellow crystals.

Sources & evidence

ORD record
ord-f3b2f6cc2fd54e15abfa2d9c8f69439c
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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