反应详情

4-Ethyl-2-thiophenecarbaldehyde (1 g, 7.13 mmol) dissolved in methanol (7 ml) was added with sodium borohydride (135 mg, 3.57 mmol) under ice cooling, stirred for 10 minutes and then further added with sodium borohydride (150 mg, 3.96 mmol) at 0° C. After the reaction solution was stirred under ice cooling for 30 minutes, the reaction was stopped with saturated aqueous ammonium chloride and the reaction solution was extracted with chloroform. The organic layer collected was dried over magnesium sulfate and concentrated under reduced pressure to obtain 1 g (100%) of the title compound without purification.

1. stirringAfter the reaction solution was stirred under ice cooling for 30 minutes
2. extractionthe reaction solution was extracted with chloroform
3. customThe organic layer collected
4. dry with materialwas dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure