8-[2-(4-ethyl-2-thienyl)ethyl]-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one → 8-[2-(4-Ethyl-2-thienyl)ethyl]-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-carbaldehyde

HRID 1828438Notes

Reaction equation

HRID 1828438 reaction equation
[OH:1][C:2]1N=C2C=C(OCC3SC=C(C(C)C)N=3)C=CN2C(=O)C=1.[CH2:23]([C:25]1[CH:26]=[C:27]([CH2:30][CH2:31][C:32]2[CH:48]=[CH:47][N:35]3[C:36](=[O:46])[CH:37]=[C:38]([N:40]4[CH2:45][CH2:44][O:43][CH2:42][CH2:41]4)[N:39]=[C:34]3[CH:33]=2)[S:28][CH:29]=1)[CH3:24]>>[CH2:23]([C:25]1[CH:26]=[C:27]([CH2:30][CH2:31][C:32]2[CH:48]=[CH:47][N:35]3[C:36](=[O:46])[C:37]([CH:2]=[O:1])=[C:38]([N:40]4[CH2:41][CH2:42][O:43][CH2:44][CH2:45]4)[N:39]=[C:34]3[CH:33]=2)[S:28][CH:29]=1)[CH3:24]

Participants

3

Reactant 2

HCID 220636008-[2-(4-ethyl-2-thienyl)ethyl]-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-oneHCID 1357244322-Hydroxy-8-[(4-isopropyl-1,3-thiazol-2-yl)methoxy]-4H-pyrido[1,2-a]pyrimidin-4-one

Product 1

HCID 220636368-[2-(4-Ethyl-2-thienyl)ethyl]-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-carbaldehyde

Procedure

Reactions were performed in the same manner as in Example 1, (I) by using 8-[2-(4-ethyl-2-thienyl)ethyl]-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one (122 mg, 0.33 mmol) as a starting material. As a result, 52 mg (40% for the three steps) of the title compound in orange color was obtained.

Sources & evidence

ORD record
ord-62020559dc59474c8b4370517164d68b
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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