4-Pyridin-4-yl-thiazol-2-ylamine → HCID 86588102, compound

HRID 1828454Notes

Reaction equation

HRID 1828454 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([NH:10][C:11]([C:13]2[CH:28]=[CH:27][N:16]3[C:17](=[O:26])[C:18]([C:21]4[N:22]=[N:23][NH:24][N:25]=4)=[CH:19][N:20]=[C:15]3[CH:14]=2)=[O:12])[S:8][CH:9]=1)(C)([CH3:3])[CH3:2].COC1C=CC(CN2N=NC(C3C(=O)N4C=CC(C(O)=O)=C[C:44]4=[N:43][CH:42]=3)=N2)=CC=1.N1C=CC(C2N=C(N)SC=2)=CC=1>>[N:43]1[CH:44]=[CH:2][C:1]([C:5]2[N:6]=[C:7]([NH:10][C:11]([C:13]3[CH:28]=[CH:27][N:16]4[C:17](=[O:26])[C:18]([C:21]5[N:25]=[N:24][NH:23][N:22]=5)=[CH:19][N:20]=[C:15]4[CH:14]=3)=[O:12])[S:8][CH:9]=2)=[CH:3][CH:42]=1

Participants

4

Reactant 3

HCID 9302374-Pyridin-4-yl-thiazol-2-ylamineHCID 22063508HCID 22063508, compoundHCID 22063552HCID 22063552, compound

Product 1

HCID 86588102HCID 86588102, compound

Procedure

Reactions were performed in the same manner as in Example 10, (F) by using 3-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxylic acid (120 mg, 0.32 mmol) and 4-(4-pyridyl)-1,3-thiazol-2-amine (62 mg, 0.35 mmol) to obtain 35.7 mg (27% for the two steps) of the title compound as orange crystals.

Sources & evidence

ORD record
ord-0b1981339f1c46148c5292624ff28f94
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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