HRID1828468

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16211918

(3S)-Piperidin-3-ol--hydrogen chloride (1/1)

C5H12ClNO

结构：CC(C)(C)c1csc(NC(=O)C2=CC3=NC(=O)CC(=O)N3C=C2)n1

HCID22063754

未命名化合物

结构：CC(C)(C)c1csc(NC(=O)c2ccn3c(=O)c(/C=C/C(=O)O)c(N4CCC[C@H](OC(N)=O)C4)nc3c2)n1

HCID23581314

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)c1csc(NC(=O)c2ccn3c(=O)cc(N4CCC[C@H](O)C4)nc3c2)n1

HCID23581335

未命名化合物

收率 62%

PROCEDURE

实验过程

Reactions were performed in the same manner as in Example 8, (E) by using N8-[4-(tert-butyl)-1,3-thiazol-2-yl]-2,4-dioxo-3,4-dihydro-2H-pyrido[1,2-a]pyrimidine-8-carboxamide (600 mg, 1.74 mmol) and (S)-(−)-3-hydroxypiperidine hydrochloride (360 mg, 2.61 mmol) to obtain 463 mg (62%) of the title compound.