HRID1828470

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)/C=C/c1c(N2CCC[C@H](OC=O)C2)nc2cc(C(=O)Nc3nc(C(C)(C)C)cs3)ccn2c1=O

HCID86588110

未命名化合物

结构：CC(C)c1csc(COc2ccn3c(=O)c(/C=C/C(=O)OC(C)(C)C)c(O)nc3c2)n1

HCID136347719

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)/C=C/c1c(N2CCC[C@H](O)C2)nc2cc(C(=O)Nc3nc(C(C)(C)C)cs3)ccn2c1=O

HCID23581336

未命名化合物

收率 73.2%

PROCEDURE

实验过程

Reactions were performed in the same manner as in Example 1, (K) by using tert-butyl (E)-3-{8-({[4-(tert-butyl)-1,3-thiazol-2-yl]amino}carbonyl)-2-[(3S)-3-formyloxyhexahydro-1-pyridinyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate (630 mg, 1.083 mmol) to obtain 439 mg (73%) of the title compound as an orange oily substance.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8c783a7e184d43a7b5135e15641d3621
来源数据集: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07056917B2
来源说明: uspto-grants-2006_06

反应 SMILES

OC1N=C2C=C(OCC3SC=C(C(C)C)N=3)C=CN2C(=O)C=1/C=C/C(OC(C)(C)C)=O.[C:32]([C:36]1[N:37]=[C:38]([NH:41][C:42]([C:44]2[CH:72]=[CH:71][N:47]3[C:48](=[O:70])[C:49](/[CH:61]=[CH:62]/[C:63]([O:65][C:66]([CH3:69])([CH3:68])[CH3:67])=[O:64])=[C:50]([N:52]4[CH2:57][CH2:56][CH2:55][C@H:54]([O:58]C=O)[CH2:53]4)[N:51]=[C:46]3[CH:45]=2)=[O:43])[S:39][CH:40]=1)([CH3:35])([CH3:34])[CH3:33]>>[C:32]([C:36]1[N:37]=[C:38]([NH:41][C:42]([C:44]2[CH:72]=[CH:71][N:47]3[C:48](=[O:70])[C:49](/[CH:61]=[CH:62]/[C:63]([O:65][C:66]([CH3:69])([CH3:68])[CH3:67])=[O:64])=[C:50]([N:52]4[CH2:57][CH2:56][CH2:55][C@H:54]([OH:58])[CH2:53]4)[N:51]=[C:46]3[CH:45]=2)=[O:43])[S:39][CH:40]=1)([CH3:35])([CH3:33])[CH3:34]