反应详情

The N1-(4-methyl-5-nitro-2-pyridyl)acetamide (4.70 g, 24.1 mmol) obtained in (A) was dissolved in ethanol (150 ml), added with 10% palladium/carbon (0.95 g) and subjected to catalytic reduction overnight at 1 atm under hydrogen atmosphere. The catalyst was removed by filtration and washed with ethanol. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography (chloroform chloroform:methanol=100:5) to obtain the title compound (4.10 g, quantitative) as brown solid.

1. customsubjected to catalytic reduction overnight at 1 atm under hydrogen atmosphere
2. customThe catalyst was removed by filtration
3. washwashed with ethanol
4. concentrationThe filtrate was concentrated
5. customthe resulting residue was purified by silica gel column chromatography (chloroform chloroform:methanol=100:5)