N-Aminomorpholine → HCID 10200416, compound

HRID 1828569Notes

Reaction equation

HRID 1828569 reaction equation
[NH2:1][N:2]1[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[CH3:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([C:28](O)=[O:29])[N:18]([CH3:27])[C:19]=2[C:20]2[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=2)=[CH:11][CH:10]=1>>[N:2]1([NH:1][C:28]([C:17]2[N:18]([CH3:27])[C:19]([C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)=[C:15]([C:12]3[CH:11]=[CH:10][C:9]([CH3:8])=[CH:14][CH:13]=3)[N:16]=2)=[O:29])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 20315N-AminomorpholineHCID 22066080HCID 22066080, compound

Product 1

HCID 10200416HCID 10200416, compound

Procedure

Using essentially the same procedure as Example 9, Step B, but using 4-aminomorpholine (0.025 mL), 4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxylic acid (25 mg, 0.08 mmol) from Example 9, Step A was converted to the title compound. HPLC/MS: 391 (M+1); Rt=3.12 min.

Sources & evidence

ORD record
ord-c6d8cca20cf44288a74e5a4f6968a2b6
Source dataset
uspto-grants-2006_06
Patent number
US07057051B2

Reaction notes

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