反应详情

温度

90 °C

A mixture of ethyl 4,5-di-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxylate (20 mg, 0.045 mmol) from Step D in neat 1-aminopiperidine (1 mL) was heated at 90° C. for 72 hr. Most of the amine was evaporated under a stream of nitrogen and the residue was purified by Prep TLC (1 mm, silica) (25% ethyl acetate in hexanes to afford the title compound. HPLC/MS: 497 (M+1), 499 (100%, M+3), 501 (M+5); Rt=3.95 min.

1. customMost of the amine was evaporated under a stream of nitrogen
2. customthe residue was purified by Prep TLC (1 mm, silica) (25% ethyl acetate in hexanes